During an endometrial biopsy, your gynecologist will remove a small sample of tissue from the lining of your uterus, called the endometrium. There are several reasons your gynecologist may recommend an endometrial biopsy, which is a short procedure that can usually be performed in your OB/GYN clinic in about 10 minutes.
Endometrial biopsies are performed in order to diagnose diseases of the endometrium. Your gynecologist may perform a biopsy to find out what is causing bleeding after menopause or persistent breakthrough bleeding, to screen for endometrial cancer, or to see how hormonal therapy is impacting your endometrial tissue. A biopsy can also be used to evaluate your fertility if you are trying to become pregnant. No anesthesia is necessary for the procedure, but your gynecologist may recommend that you take over-the-counter pain medication or a sedative before your biopsy for your comfort.